Introduction to Hematology Analysis – A Simple Guide

What is hematology analysis?


Hematology is the study of blood and how it affects overall health and disease. Blood, blood proteins, and blood-producing organs are all tested as part of hematology. Infection, anemia, inflammation, hemophilia, blood-clotting problems, leukemia, and the body’s response to chemotherapy treatments are all illnesses that can be evaluated with these tests. In many circumstances, the results of a blood test can provide a precise assessment of a patient’s physical conditions and how internal and external influences may affect their health. Both manual and electronic methods can be employed to perform these tests. The frequency of hematological examination influences the method of analysis chosen. An increasing frequency of hematological analysis necessitates the use of electronic analysis technologies.

Blood cell formation


Hematopoiesis, or blood cell creation, is a continual process in which the cellular constituents of blood are regenerated as needed. Blood cells are formed in specific blood-forming organs, such as the marrow of some bones. The bone marrow makes all of the red blood cells, including about 60–70 per cent of the white cells (granulocytes) and all of the platelets in an adult human. The bone marrow produces half a litre (nearly one pint) of red blood cells every week in a healthy adult. The perfect equilibrium between red cell production and red cell elimination from the circulation is also maintained. The rate at which blood cells are formed varies from person to person, but on average, 200 billion red cells, 10 billion white cells, and 400 billion platelets are produced per day.

what is a hematology analyzer?


Hematology analyzer are machines that run tests on blood samples. In medicine, they are used to perform white blood cell counts, complete blood counts, reticulocyte analyses, and coagulation assays. Closed vial testing and open sampling testing are two features that differ amongst hematology analyzers. Some hematology analyzers even allow the user to select the type of testing they want.

Basic analyzers return a complete blood count (CBC) with a three-part differential white blood cell (WBC) count.  Advanced analyzers that examine cell morphology and detect small cell populations are used to diagnose rare blood disorders. Electrical impedance, flow cytometry, and fluorescent flow cytometry are the three most common physical technologies in hematology analyzers. To extend the quantifiable parameters, these are used with chemical reagents that lyse or change blood cells. Manufacturers integrate these three technologies and data analysis tools to create proprietary methodologies, each with its own set of advantages in terms of accuracy, speed, and parameter breadth.


Hematology 3-part analyzers versus 5-part analyzers


A three-part differential is a simple blood test. A five-part differential is when a more thorough and in-depth study of the blood is performed simultaneously to offer up additional possibilities for the outcome. The three-part blood cell analyzer is primarily intended for hospitals that are not in the Top Three categories, such as maternal and child hospitals, clinics, and community hospitals. It is less expensive than a five-part hematological analyzer and fits their clinical needs. Hematology analyzer with a five-part system End users are primarily people who work at hospitals not among the top three. The prices of the machine and reagents are higher than those of a three-part hematological analyzer.

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